芳基
化学
催化作用
镍
电泳剂
偶联反应
组合化学
非甾体
联轴节(管道)
有机化学
还原消去
材料科学
烷基
医学
药理学
冶金
作者
Haixing Guan,Qianwen Zhang,Patrick J. Walsh,Jianyou Mao
标识
DOI:10.1002/anie.201914175
摘要
Abstract A unique nickel/organic photoredox co‐catalyzed asymmetric reductive cross‐coupling between α‐chloro esters and aryl iodides is developed. This cross‐electrophile coupling reaction employs an organic reductant (Hantzsch ester), whereas most reductive cross‐coupling reactions use stoichiometric metals. A diverse array of valuable α‐aryl esters is formed under these conditions with high enantioselectivities (up to 94 %) and good yields (up to 88 %). α‐Aryl esters represent an important family of nonsteroidal anti‐inflammatory drugs. This novel synergistic strategy expands the scope of Ni‐catalyzed reductive asymmetric cross‐coupling reactions.
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