医学
膀胱过度活动
抗胆碱能
四分位间距
内科学
尿失禁
抗胆碱药
泌尿科
物理疗法
病理
替代医学
作者
David Sheyn,Adonis Hijaz,Fred E. Hazlett,Sherif El-Nashar,Jeffrey Mangel,Xin Li,Emily Mara,Sahil Mahajan
出处
期刊:Female pelvic medicine & reconstructive surgery
[Ovid Technologies (Wolters Kluwer)]
日期:2020-12-01
卷期号:26 (12): e91-e96
被引量:4
标识
DOI:10.1097/spv.0000000000000787
摘要
Objective This study aimed to determine whether levels of choline (Ch) and acetylcholine (Ach) differ between responders and nonresponders to anticholinergic therapy. Methods Patients prescribed an anticholinergic were evaluated using the Overactive Bladder Symptom Score; Medical, Epidemiologic and Social Aspects of Aging and Incontinence Questionnaire; and Incontinence Impact Questionnaire-7. A 1-day voiding diary and a urine sample were collected. After treatment for 12 weeks, the questionnaires were administered and 1-day voiding diary was completed. Levels of Ach and Ch were measured by liquid chromatography with tandem mass spectrometry. Subjects were divided into responders and nonresponders. Wilcoxon rank sum test and Fisher exact test were used to express differences between groups. Spearman ρ correlation coefficient was used to determine the relationship between Ach and Ch and symptom severity, patient demographics, and questionnaire scores. Results Thirty-one women were included in the analysis. The treatment response rate was 48.8%. The median age was 67 years (interquartile range, 50–76 years), and median body mass index was 32.3 kg/m 2 (27.5–40.6 kg/m 2 ), with 41.2% having an additional complaint of stress incontinence. There were no significant differences in symptom severity or questionnaire scores between groups. The median Ch and Ach levels were higher in responders (28.6 vs 9.2 μL, P = 0.04) and (83.1 vs 18.7 nL, P = 0.02), respectively. Levels of both Ch and Ach had moderate positive correlations with the Medical, Epidemiologic and Social Aspects of Aging and Incontinence Questionnaire urgency urinary incontinence score (ρ = 0.533 [ P = 0.002] and ρ = 0.453 [ P = 0.01], respectively). Conclusion In women with overactive bladder, urinary Ach and Ch levels are higher in responders to anticholinergic therapy compared with nonresponders.
科研通智能强力驱动
Strongly Powered by AbleSci AI