链脲佐菌素
神经调节蛋白1
周围神经病变
糖尿病神经病变
肠道菌群
医学
糖尿病
神经调节蛋白
药理学
内科学
内分泌学
免疫学
受体
作者
Jun Xie,Wei Song,Xuan Liang,Qian Zhang,Yue Shi,Wei Liu,Xiaohu Shi
出处
期刊:Aging
[Impact Journals, LLC]
日期:2020-09-13
卷期号:12 (17): 17436-17458
被引量:9
标识
DOI:10.18632/aging.103750
摘要
Jinmaitong (JMT), a compound prescription of traditional Chinese medicine, has long been used as a therapy for diabetic peripheral neuropathy (DPN). However, the neuroprotective mechanisms of JMT and its effect on gut microbiota remained unknown. Here, we examined the effects of JMT on behavior, pathomorphology and gut microbiota in streptozotocin (STZ)-induced DPN rats. Compared to distilled water administration, JMT reversed decreases in mechanical withdraw threshold and intraepidermal nerve fiber density, improved neurological morphology of sciatic nerves, increased serum neuregulin 1 (NRG1) level and contactin-associated protein (Caspr)-positive paranodes, and decreased amyloid precursor protein (APP) accumulation in DPN rats. More importantly, JMT enriched nine species of the gut microbiota of DPN rats, helping to prevent dysbiosis. Among these species, p_Actinobacteria, p_Proteobacteria and c_Actinobacteria were negatively correlated with DPN phenotypes and positively correlated with serum NRG1 level. These results indicate that JMT may exert a neuroprotective effect by modulating phenotype-associated gut microbiota and increasing serum NRG1 level in STZ-induced DPN rats. JMT may therefore be an effective complementary and alternative anti-DPN therapy.
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