粒体自噬
生殖毒性
帕金
品脱1
线粒体
生殖系统
毒性
精子发生
线粒体分裂
细胞凋亡
男科
精子
自噬
生物
内科学
内分泌学
医学
细胞生物学
生物化学
疾病
帕金森病
作者
Lu Kong,Jiahui Dong,Wenhui Lü,Yongya Wu,Lin Liu,Meng Tang
出处
期刊:NanoImpact
[Elsevier]
日期:2021-07-01
卷期号:23: 100350-100350
被引量:6
标识
DOI:10.1016/j.impact.2021.100350
摘要
Nickel nanoparticles (Ni NPs) have a wide range of application prospects, however there is still a lack of their safety evaluation for the reproductive system. Nowadays, male reproductive health has been widely concerned for the increasing incidence of male infertility. To investigate the male reproductive toxicity induced by Ni NPs and its relation with the mitochondrial fission and mitophagy, male mice were administered with or without 5, 15, and 45 mg/kg of Ni NPs by intratracheal instillation. At the end of intervention, sex hormone level, sperm abnormality rate, pathological morphology of testis, cell apoptosis and the expression levels of Drp1, Pink1 and Parkin proteins in testis tissues were detected. The results indicated that the rate of sperm deformity and serum levels of reproductive hormones increased obviously with the increasing concentrations of Ni NPs. Testicular spermatogenic cells were damaged and the number of apoptotic cells increased significantly. Furthermore, the expressions of key proteins (Drp1, Pink1 and Parkin) related to mitochondrial fission/autophagy in testis tissues also increased after exposure to Ni NPs. Collectively, mitochondria damage may play an important role in male mice reproductive toxicity induced by the intratracheal instillation of Ni NPs.
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