Validation and accuracy evaluation of automatic segmentation for knee joint pre-planning

Proper use of three-dimensional (3D) models generated from medical imaging data in clinical preoperative planning, training and consultation is based on the preliminary proved accuracy of the replication of the patient anatomy. Therefore, this study investigated the dimensional accuracy of 3D reconstructions of the knee joint generated from computed tomography scans via automatic segmentation by comparing them with 3D models generated through manual segmentation.Three unpaired, fresh-frozen right legs were investigated. Three-dimensional models of the femur and the tibia of each leg were manually segmented using a commercial software and compared in terms of geometrical accuracy with the 3D models automatically segmented using proprietary software. Bony landmarks were identified and used to calculate clinically relevant distances: femoral epicondylar distance; posterior femoral epicondylar distance; femoral trochlear groove length; tibial knee center tubercle distance (TKCTD). Pearson's correlation coefficient and Bland and Altman plots were used to evaluate the level of agreement between measured distances.Differences between parameters measured on 3D models manually and automatically segmented were below 1 mm (range: -0.06 to 0.72 mm), except for TKCTD (between 1.00 and 1.40 mm in two specimens). In addition, there was a significant strong correlation between measurements.The results obtained are comparable to those reported in previous studies where accuracy of bone 3D reconstruction was investigated. Automatic segmentation techniques can be used to quickly reconstruct reliable 3D models of bone anatomy and these results may contribute to enhance the spread of this technology in preoperative and operative settings, where it has shown considerable potential.