化学
硝基苯
三氟甲基
光催化
催化作用
光化学
组合化学
药物化学
有机化学
烷基
作者
Samir Bouayad‐Gervais,Christian D.-T. Nielsen,Abdurrahman Türksoy,Theresa Sperger,Kristina Deckers,Franziska Schoenebeck
摘要
We report the mild activation of carbamoyl azides to the corresponding nitrenes using a blue light/[Ir]-catalyzed strategy, which enables stereospecific access to N-trifluoromethyl imidazolidinones and benzimidazolones. These novel structural motifs proved to be highly robust, allowing their downstream diversification. On the basis of our combined computational and experimental studies, we propose that an electron rebound with the excited metal catalyst is undergone, involving a reduction-triggered nitrogen loss, followed by oxidation to the corresponding carbamoyl nitrene and subsequent C-H insertion.
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