高强度
磁共振成像
心脏病学
白质
灌注
医学
脑血流
磁化率加权成像
灌注扫描
内科学
核医学
病理
作者
Meher R Juttukonda,Kimberly A Stephens,Yi-Fen Yen,Casey M Howard,Jonathan R. Polimeni,Bruce R Rosen,David H Salat
标识
DOI:10.1177/0271678x221105986
摘要
White matter lesions (WML) have been linked to cognitive decline in aging as well as in Alzheimer’s disease. While hypoperfusion is frequently considered a cause of WMLs due to the resulting reduction in oxygen availability to brain tissue, such reductions could also be caused by impaired oxygen exchange. Here, we tested the hypothesis that venous hyperintense signal (VHS) in arterial spin labeling (ASL) magnetic resonance imaging (MRI) may represent a marker of impaired oxygen extraction in aging older adults. In participants aged 60–80 years (n = 30), we measured cerebral blood flow and VHS with arterial spin labeling, maximum oxygen extraction fraction (OEF max ) with dynamic susceptibility contrast, and WML volume with T 1 -weighted MRI. We found a significant interaction between OEF max and VHS presence on WML volume ( p = 0.02), where lower OEF max was associated with higher WML volume in participants with VHS, and higher OEF max was associated with higher WML volume in participants without VHS. These results indicate that VHS in perfusion-weighted ASL data may represent a distinct cerebrovascular aging pattern involving oxygen extraction inefficiency as well as hypoperfusion.
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