Global evolution and geographic diversity of hypervirulent carbapenem-resistant Klebsiella pneumoniae

In a large-scale, prospective, intercontinental study, Minggui Wang and colleagues1 used whole-genome sequencing (WGS) and clinical investigations to show regional differences in the epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP). From 71 hospitals in eight countries, 991 strains of CRKP were collected to establish their clinical, epidemiological, and genomic characteristics. The authors noted regional differences between bacterial characteristics of CRKP populations and their associated patient cohorts.