阴道镜检查
细胞学
急诊分诊台
医学
介绍
信使核糖核酸
妇科
宫颈上皮内瘤变
巴氏试验
宫颈癌
内科学
癌症
生物
宫颈癌筛查
病理
基因
遗传学
家庭医学
急诊医学
作者
Paolo Giorgi Rossi,Guglielmo Ronco,Pamela Mancuso,Francesca Carozzi,Elena Allìa,Simonetta Bisanzi,Anna Gillio‐Tos,Laura De Marco,Raffaella Rizzolo,Daniela Gustinucci,Annarosa Del Mistro,Helena Frayle,Massimo Confortini,Anna Iossa,Elena Nardi Cesarini,Simonetta Bulletti,Basilio Passamonti,Silvia Gori,Laura Toniolo,Alessandra Barca,Laura Bonvicini,Francesco Venturelli,Maria Benevolo
摘要
As the primary screening test, E6/E7 mRNA has shown similar sensitivity for CIN3+ and lower positivity rate than the HPV DNA test. Nevertheless, the overall mRNA positivity is too high for immediate colposcopy, making a triage test necessary. The aim was to estimate the mRNA performance as a primary test with different triage strategies. All HPV DNA-positives were tested for mRNA, cytology and p16/ki67. A sample of HPV DNA-negatives was also tested for mRNA to estimate test specificity. We included all CIN3+ histologically diagnosed within 24 months since recruitment. Of the 41 127 participants, 7.7% were HPV DNA-positive, of which 66.4% were mRNA-positive. Among the HPV DNA-negatives, 10/1108 (0.9%) were mRNA-positive. Overall, 97 CIN3+ were found. If mRNA was used as the primary test, it would miss about 3% of all CIN3+ with a 22% reduction of positivity compared with HPV DNA. The weighted specificity estimate for
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