表观遗传学
细胞骨架
细胞生物学
吸入
病态的
肺
肌动蛋白细胞骨架
机制(生物学)
医学
基因
生物
病理
遗传学
内科学
解剖
细胞
哲学
认识论
作者
Yanting Li,Teng Shi,Xin Li,Haichun Sun,Xiaowen Xia,Xiaoya Ji,Jianzhong Zhang,Meike Liu,Yongfeng Lin,Rong Zhang,Yuxin Zheng,Jinglong Tang
标识
DOI:10.1016/j.envint.2022.107257
摘要
Tire wear microplastic particles (TWMPs) are emerging microplastic pollutants that have gained increasing attention lately. However, the health effect of inhaled airborne TWMPs has never been explored before and may already be included in particulate matter morbidity and mortality. Here, we endeavored to address the preliminary study of TWMP inhalation-induced pulmonary toxic effects and its epigenetic mechanisms in C57BL/6 mice. As a result, restricted ventilatory dysfunction and fibrotic pathological changes were observed in TWMP-treaded mice. Further research found that attenuation of miR-1a-3p plays an important role in TWMP-induced lung injury. Results from in vitro study confirmed that cytoskeleton regulatory gene twinfilin-1 was one of the target genes of miR-1a-3p, and involved in cytoskeleton rearrangement caused by TWMP exposure. Mechanistically, miR-1a-3p inhibited the F-actin formation by targeting cytoskeletal regulatory proteins twinfilin-1, leading to TWMP-induced pulmonary fibrotic injury. While we are in the very early stages of explaining the role of epigenetics in TWMP-induced lung injury, the potential for the use of epigenetic marks as biomarkers is high and discoveries made in this field will likely bring us closer to better understanding this crucial mechanism.
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