干细胞
神经干细胞
材料科学
Wnt信号通路
细胞生物学
细胞分化
生物相容性
细胞生长
生物
信号转导
生物化学
基因
冶金
作者
Wenjuan Ma,Xin Shao,Dan Zhao,Qianshun Li,Mengting Liu,Tengfei Zhou,Xueping Xie,Chenchen Mao,Yuxin Zhang,Yunfeng Lin
标识
DOI:10.1021/acsami.8b00833
摘要
Stem cell-based therapy is considered a promising approach for the repair of nervous tissues. Neural stem cells (NSCs) cannot proliferate or differentiate efficiently; hence, different biomaterials have been explored to improve NSC proliferation and differentiation. However, these agents either had low bioavailability or poor biocompatibility. In this work, our group investigated the effects of tetrahedral DNA nanostructures (TDNs), a novel DNA biological material, on the self-renew and differentiation of neuroectodermal (NE-4C) stem cells. We observed that TDN treatment promoted self-renew of the stem cells via activating the Wnt/β-catenin pathway. In addition, our findings suggested that NE-4C stem cells’ neuronal differentiation could be promoted effectively by TDNs via inhibiting the notch signaling pathway. In summary, this is the first report about the effects of TDNs on the proliferation and differentiation of NE-4C stem cells and the results demonstrate that TDNs have a great potential in nerve tissue regeneration.
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