陶氏病
低聚物
τ蛋白
蛋白质聚集
淀粉样蛋白(真菌学)
小分子
毒性
化学
Tau病理学
疾病
生物
神经科学
阿尔茨海默病
生物化学
医学
神经退行性变
病理
无机化学
有机化学
作者
Julia E. Gerson,Filippa Lo Cascio,Rakez Kayed
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2017-01-01
卷期号:: 97-121
被引量:2
标识
DOI:10.1016/b978-0-12-803690-7.00006-5
摘要
Abstract The accumulation of pathological protein deposits, amyloids, in neurodegenerative disease represents a formidable challenge for drug development. With no effective treatment in sight, and recent findings suggesting that protein aggregates are diverse, dynamic, and capable of spreading, it is crucial that researchers find safe and successful therapeutic approaches that target the most toxic amyloid species. The pathological aggregation of microtubule-associated protein tau has been identified as a critical factor in the progression of Alzheimer’s disease and other neurodegenerative disorders. More evidence continues to come to light to suggest that soluble, intermediate tau aggregates—tau oligomers—are the most toxic species in disease and may be responsible for the spread of pathology, rather than neurofibrillary tangles, the primary tauopathy hallmark, suggesting that oligomeric tau may be the best therapeutic target. Here we discuss the potential of small molecules in preventing amyloid and tau oligomer toxicity and future directions.
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