Patient-oriented research (POR) is a specific type of clinical translational research where the patient is the focus of the investigation. This type of investigation requires interaction with the patient to test the research hypotheses and perform the studies. POR plays an important role in many types of clinical translational research including observational, mechanistic, and therapeutic studies as well as clinical trials. POR can fill the translational gap between basic science research and clinical applications to humans as well as the gap between clinical research findings and their use by the community. There are several important steps to successful POR investigation many of which are common to research in general but have specific considerations when human subjects are involved.