赫拉
酰亚胺
MTT法
化学
对接(动物)
蒽
细胞毒性
立体化学
组合化学
细胞生长
有机化学
生物化学
细胞
体外
医学
护理部
作者
Maha Abdul Razaq Essa,Adil Muala Dhumad
出处
期刊:International Journal of Health Sciences (IJHS)
[Suryasa and Sons]
日期:2022-10-24
卷期号:: 546-560
标识
DOI:10.53730/ijhs.v6ns10.13537
摘要
A number of cyclic imide derivatives were prepared in this study, using Diels- Alder reaction as a first step between maleic anhydride and anthracene. Use the reaction product as a reactant in the second step with different amines. The prepared cyclic imides were characterized by following the known spectroscopic methods to prove the proposed chemical composition of each of them using Mass, FT-IR, 1HNMR and 13CNMR. The biological activity of the prepared cyclic imides was tested theoretically using molecular docking to prove their efficacy as candidate inhibitors of breast and cervical cancer. The efficacy of prepared cyclic imides as inhibitors and antagonists of breast and cervical cancer, a practical candidate using the MTT assay to measure cellular metabolic activity as an indicator of cell viability, proliferation and cytotoxicity in MCF-7 and HeLa cell lines. Cytotoxic effects were in agreement with the molecular docking calculations, as the prepared cyclic imide derivatives showed good activity in inhibiting breast and cervical cancer cells. The results of MTT assay and molecular docking scores proved that the prepared (11R,15S)-13-(3-nitrophenyl)-9,10-dihydro-9,10-[3,4]epipyrrolo-anthracene-12,14-di one derivative a3 is considered as a potential candidate inhibitor for cervical cancer.
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