ABSTRACT Introduction Despite the established link between obesity and erectile dysfunction (ED) and the alarming rise in global obesity rates, awareness of this connection remains lacking in clinical practice and among patients. This systematic literature review aimed to investigate the frequency of ED in patients with obesity. Methods A systematic review was conducted following the PRISMA guidelines. PubMed and gray literature sources were searched for studies evaluating the incidence and prevalence of ED in individuals with a BMI of ≥ 25 kg/m 2 . Results Of 554 identified records, 23 studies met the eligibility criteria and were included in the qualitative synthesis. The studies comprised 52,981 participants, with 18,104 men classified as having overweight or obesity. The prevalence of ED in men with overweight and obesity varied globally, with higher percentages observed in older age groups and those with additional risk factors. Inconsistencies in BMI classifications and diverse methods of ED assessment complicated direct comparisons across studies. Conclusion This review underscores the urgent need for standardized reporting of ED rates among men with obesity. The inconsistent prevalence rates and varied BMI classifications hinder clear conclusions. Further research is needed to ensure comprehensive care for individuals affected by both conditions.