脂肪组织
白色脂肪组织
病理生理学
炎症
脂肪细胞
医学
内分泌学
肥胖
内科学
肌肉肥大
内皮功能障碍
生物信息学
生物
作者
Natalia Santillana,Camila Astudillo-Guerrero,Amanda D’Espessailles,Gonzalo Cruz
出处
期刊:Nutrients
[MDPI AG]
日期:2023-03-31
卷期号:15 (7): 1722-1722
被引量:8
摘要
White adipose tissue (AT) dysfunction plays an important role in the development of cardiometabolic alterations associated with obesity. AT dysfunction is characterized by the loss of the expansion capacity of the AT, an increment in adipocyte hypertrophy, and changes in the secretion profile of adipose cells, associated with accumulation of macrophages and inflammation. Since not all people with an excess of adiposity develop comorbidities, it is necessary to find simple tools that can evidence AT dysfunction and allow the detection of those people with the potential to develop metabolic alterations. This review focuses on the current pathophysiological mechanisms of white AT dysfunction and emerging measurements to assess its functionality.
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