癌症
神经内分泌分化
细胞分化
癌症研究
生物
转录因子
下调和上调
遗传学
生物化学
基因
前列腺癌
作者
Wen Ding,Jianzheng Zhu,Jianshan Mo,Shumin Ouyang,Guopin Liu,Yingxue Su,Danyuan Sun,Jiangling Ye,Yanyan Wu,Jiayu Yan,Menghan Xue,Peibin Yue,Jin‐Jian Lu,Libin Wang,Yandong Wang,Xiaolei Zhang
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2025-08-26
卷期号:85 (22): 4469-4484
被引量:3
标识
DOI:10.1158/0008-5472.can-25-0405
摘要
VGF is a therapeutic target in small cell lung cancer that promotes expression of ASCL1 to drive neuroendocrine differentiation and mediates lactate exchange between cancer cells and fibroblasts in the tumor microenvironment.
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