PCSK9
前蛋白转化酶
可欣
低密度脂蛋白受体
前蛋白转化酶类
枯草杆菌素
临床试验
药理学
化学
胆固醇
医学
脂蛋白
生物化学
内科学
酶
作者
Enrico Mario Alessandro Fassi,Andrea Citarella,Marco Albani,Erica Ginevra Milano,Laura Legnani,Carmen Lammi,Alessandra Silvani,Giovanni Grazioso
标识
DOI：10.1080/13543776.2024.2340569
摘要
Proprotein convertase subtilisin/kexin 9 (PCSK9) plays a crucial role in breaking down the hepatic low-density lipoprotein receptor (LDLR), thereby influencing the levels of circulating low-density lipoprotein cholesterol (LDL-C). Consequently, inhibiting PCSK9 through suitable ligands has been established as a validated therapeutic strategy for combating hypercholesterolemia and cardiovascular diseases.
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