内皮功能障碍
糖尿病
线粒体
病理生理学
医学
生物信息学
内皮干细胞
生物
细胞生物学
内科学
内分泌学
生物化学
体外
作者
Xuefeng Fang,Yanjiao Zhang,Haoran Wu,Wei Han,Runyu Miao,Jiahua Wei,Yuxin Zhang,Jiaxing Tian,Xiaolin Tong
标识
DOI:10.1016/j.biocel.2024.106569
摘要
Micro- and macrovascular complications frequently occur in patients with diabetes, with endothelial dysfunction playing a key role in the development and progression of the complications. For the early diagnosis and optimal treatment of vascular complications associated with diabetes, it is imperative to comprehend the cellular and molecular mechanisms governing the function of diabetic endothelial cells. Mitochondria function as crucial sensors of environmental and cellular stress regulating endothelial cell viability, structural integrity and function. Impaired mitochondrial quality control mechanisms and mitochondrial dysfunction are the main features of endothelial damage. Hence, targeted mitochondrial therapy is considered promising novel therapeutic options in vascular complications of diabetes. In this review, we focus on the mitochondrial functions in the vascular endothelial cells and the pathophysiological role of mitochondria in diabetic endothelial dysfunction, aiming to provide a reference for related drug development and clinical diagnosis and treatment.
科研通智能强力驱动
Strongly Powered by AbleSci AI