Dynamic Susceptibility Contrast Perfusion, Part 1: The Fundamentals

Measuring blood flow has been of long-standing interest in medicine and physiology. Initially conceived to measure blood flow to the whole organ, attention turned quickly to measure capillary blood flow as a measure of local delivery of nutrients to a small region of tissue. Originally proposed with gases and microspheres, early on, the method of indicator dilution has become the most prevalent approach because of the impracticality of using microspheres.