致病岛
原噬菌体
生物
毒力
转导(生物物理学)
遗传学
水平基因转移
基因
基因组
噬菌体
大肠杆菌
生物化学
作者
Melissa Su Juan Chee,Ester Serrano,Yin Ning Chiang,Joshua D. Harling-Lee,Robert A. de Man,Rodrigo Bacigalupe,J. Ross Fitzgerald,José R. Penadés,John Chen
出处
期刊:Cell
[Elsevier]
日期:2023-08-01
卷期号:186 (16): 3414-3426.e16
被引量:2
标识
DOI:10.1016/j.cell.2023.07.001
摘要
Summary
Lateral transduction (LT) is the process by which temperate phages mobilize large sections of bacterial genomes. Despite its importance, LT has only been observed during prophage induction. Here, we report that superantigen-carrying staphylococcal pathogenicity islands (SaPIs) employ a related but more versatile and complex mechanism of gene transfer to drive chromosomal hypermobility while self-transferring with additional virulence genes from the host. We found that after phage infection or prophage induction, activated SaPIs form concatamers in the bacterial chromosome by switching between parallel genomic tracks in replication bubbles. This dynamic life cycle enables SaPIbov1 to piggyback its LT of staphylococcal pathogenicity island vSaα, which encodes an array of genes involved in host-pathogen interactions, allowing both islands to be mobilized intact and transferred in a single infective particle. Our findings highlight previously unknown roles of pathogenicity islands in bacterial virulence and show that their evolutionary impact extends beyond the genes they carry.
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