47.1.2.5 Allylic C—H Functionalization

Abstract The direct functionalization of allylic C(sp3)—H bonds allows alkenes to serve as versatile allylating agents capable of undergoing diverse bond-forming reactions, thereby enabling rapid access to alkene-bearing structural complexity from readily accessible feedstocks. In this review, representative reports on allylic C—H functionalization reactions published since 2013 are summarized by describing six types of allylic C—H activation modes: C—H insertion, hydrogen-atom transfer, concerted metalation/deprotonation (CMD), concerted proton and two-electron transfer (CPTET), base-mediated C—H activation, and oxidative addition to C-H bonds.