化学
烯胺
铑
卡宾
形式综合
反应性(心理学)
级联
立体化学
药物化学
催化作用
组合化学
有机化学
色谱法
医学
病理
替代医学
作者
Yuchen Jie,Huiqin Hu,Zefeng Xu,Shengguo Duan,Chuan‐Ying Li
标识
DOI:10.1002/adsc.202201187
摘要
Abstract 3‐Methylidene‐2,3‐dihydropyrroles with an ester or keto group at the C4 position were obtained in moderate to good yields from enamine‐tethered triazoles in the presence of a rhodium(II) catalyst. A formal 1,2‐enamine migration/cyclization cascade triggered by formation of an α‐amino carbene is proposed to illustrate the mechanism. The valuable exocyclic double bond showed distinctive reactivity, which is very useful for further introduction of functional groups. The dihydropyrrole is stable under neutral, weakly acidic, or weakly basic conditions. magnified image
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