Covalent Organic Framework: A Rising Star in Antibacterial Agents

Abstract In the face of the escalating antibiotic resistance crisis, the world is embroiled in a silent “antibacterial war”. Scientists are actively searching for innovative antibacterial materials that can be used as effective weapons against bacterial infections. As promising new crystalline porous polymer materials, covalent organic frameworks (COFs) are gradually revealing their vast potential in antibacterial applications. This study investigates the classification of COF‐based antibacterial agents, provides a comprehensive overview of their applications and research advancements, and explores the antibacterial strategies employed by COF materials. Furthermore, the challenges are outlined that lie ahead for the future application of COF antibacterial agents and insights into their promising prospects within the antibacterial field are offered. Through these efforts, the aim is to accelerate advancements in COFs manufacturing technology, promote innovation in COF‐based antibacterial applications, and contribute to public health.