Predicting and assessing the toxicity and ecological risk of seven widely used neonicotinoid insecticides and their aerobic transformation products to aquatic organisms

Neonicotinoid insecticides (NIs) are widely used worldwide, accounting for 25 % of the global insecticide market, and are easily transported into surrounding aquatic ecological environments after application. At present, >80 % of surface water is contaminated by NIs globally. Some transformation products (TPs) of NIs can exhibit greater toxicity to aquatic organism than their parent products. However, few studies have evaluated the toxicity and ecological risk of the TPs of NIs. In this study, we aimed to assess the toxicity and ecological risk of seven widely used NIs and their aerobic TPs to aquatic organisms using a prediction method. We found that partial aerobic TPs of NIs have greater toxicity to aquatic organisms than their parent products, and some of them could severely damage aquatic ecosystems. Meanwhile, acetamiprid, thiacloprid, and several other TPs of NIs with a chlorinated ring structure showed strong bioconcentration abilities, which could potentially harm aquatic organisms through the food chain. Moreover, the widespread use of NIs has certain aquatic ecological risks, which should be controlled and limited. This study comprehensively evaluated the ecological risk of seven widely used NIs and their aerobic TPs to aquatic organisms for the first time. Our results could provide an important reference for assessment of the aquatic environmental risk posed by NIs and pollution control.