效应器
生物
白细胞介素-7受体
存储单元
异位表达
细胞生物学
前体细胞
免疫学
免疫系统
癌症研究
T细胞
分子生物学
细胞
细胞培养
遗传学
白细胞介素2受体
物理
晶体管
量子力学
电压
作者
Wenxiang Sun,Erik P. Hughes,Hee Joo Kim,Jelena Perovanović,Krystal R. Charley,Bryant Perkins,Junhong Du,Andrea Ibarra,Amber R. Syage,J. Scott Hale,Matthew A. Williams,Dean Tantin
标识
DOI:10.1073/pnas.2309153121
摘要
The molecular mechanisms leading to the establishment of immunological memory are inadequately understood, limiting the development of effective vaccines and durable antitumor immune therapies. Here, we show that ectopic OCA-B expression is sufficient to improve antiviral memory recall responses, while having minimal effects on primary effector responses. At peak viral response, short-lived effector T cell populations are expanded but show increased Gadd45b and Socs2 expression, while memory precursor effector cells show increased expression of Bcl2, Il7r, and Tcf7 on a per-cell basis. Using an OCA-B mCherry reporter mouse line, we observe high OCA-B expression in CD4+ central memory T cells. We show that early in viral infection, endogenously elevated OCA-B expression prospectively identifies memory precursor cells with increased survival capability and memory recall potential. Cumulatively, the results demonstrate that OCA-B is both necessary and sufficient to promote CD4 T cell memory in vivo and can be used to prospectively identify memory precursor cells.
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