摘要
HomeCirculation ResearchVol. 134, No. 1Shedding Light on the Roles of Ceramide in Human Microvascular Function No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextShedding Light on the Roles of Ceramide in Human Microvascular Function Charles D. Searles Charles D. SearlesCharles D. Searles Correspondence to: Charles D. Searles, MD, Atlanta VA Medical Center, Emory University, 1670 Clairmont Rd, Mailstop 111B, Decatur, GA 30033. Email E-mail Address: [email protected] https://orcid.org/0000-0001-9469-0564 Atlanta VA Healthcare System, Decatur, GA. Emory University, Atlanta, GA. Search for more papers by this author Originally published4 Jan 2024https://doi.org/10.1161/CIRCRESAHA.123.323868Circulation Research. 2024;134:97–99This article is a commentary on the followingNecessary Role of Ceramides in the Human Microvascular Endothelium During Health and DiseaseFootnotesFor Sources of Funding and Disclosures, see page 99.The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Correspondence to: Charles D. Searles, MD, Atlanta VA Medical Center, Emory University, 1670 Clairmont Rd, Mailstop 111B, Decatur, GA 30033. Email csearle@emory.eduREFERENCES1. Boerhout CKM, de Waard GA, Lee JM, Mejia-Renteria H, Lee SH, Jung JH, Hoshino M, Echavarria-Pinto M, Meuwissen M, Matsuo H, et al. Prognostic value of structural and functional coronary microvascular dysfunction in patients with non-obstructive coronary artery disease; from the multicentre international ILIAS registry.EuroIntervention. 2022; 18:719–728. doi: 10.4244/EIJ-D-22-00043CrossrefMedlineGoogle Scholar2. Beyer AM, Gutterman DD. Regulation of the human coronary microcirculation.J Mol Cell Cardiol. 2012; 52:814–821. doi: 10.1016/j.yjmcc.2011.10.003CrossrefMedlineGoogle Scholar3. Zinkevich NS, Fancher IS, Gutterman DD, Phillips SA. Roles of NADPH oxidase and mitochondria in flow-induced vasodilation of human adipose arterioles: ROS-induced ROS release in coronary artery disease.Microcirculation. 2017; 24:10.1111/micc.12380. doi: 10.1111/micc.12380CrossrefGoogle Scholar4. Laaksonen R, Ekroos K, Sysi-Aho M, Hilvo M, Vihervaara T, Kauhanen D, Suoniemi M, Hurme R, Marz W, Scharnagl H, et al. Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol.Eur Heart J. 2016; 37:1967–1976. doi: 10.1093/eurheartj/ehw148CrossrefMedlineGoogle Scholar5. Zietzer A, Dusing P, Reese L, Nickenig G, Jansen F. Ceramide metabolism in cardiovascular disease: a network with high therapeutic potential.Arterioscler Thromb Vasc Biol. 2022; 42:1220–1228. doi: 10.1161/ATVBAHA.122.318048LinkGoogle Scholar6. Lallemand T, Rouahi M, Swiader A, Grazide MH, Geoffre N, Alayrac P, Recazens E, Coste A, Salvayre R, Negre-Salvayre A, et al. nSMase2 (type 2-neutral sphingomyelinase) deficiency or inhibition by GW4869 reduces inflammation and atherosclerosis in Apoe-/- mice.Arterioscler Thromb Vasc Biol. 2018; 38:1479–1492. doi: 10.1161/ATVBAHA.118.311208LinkGoogle Scholar7. Freed JK, Beyer AM, LoGiudice JA, Hockenberry JC, Gutterman DD. Ceramide changes the mediator of flow-induced vasodilation from nitric oxide to hydrogen peroxide in the human microcirculation.Circ Res. 2014; 115:525–532. doi: 10.1161/CIRCRESAHA.115.303881LinkGoogle Scholar8. De Palma C, Meacci E, Perrotta C, Bruni P, Clementi E. Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium.Arterioscler Thromb Vasc Biol. 2006; 26:99–105. doi: 10.1161/01.ATV.0000194074.59584.42LinkGoogle Scholar9. Cantalupo A, Gargiulo A, Dautaj E, Liu C, Zhang Y, Hla T, Di Lorenzo A. S1PR1 (sphingosine-1-phosphate receptor 1) signaling regulates blood flow and pressure.Hypertension. 2017; 70:426–434. doi: 10.1161/HYPERTENSIONAHA.117.09088LinkGoogle Scholar10. SenthilKumar GKB, Zirgibel Z, Lindemer B, Jaramillo-Torres MJ, Bordas-Murphy H, Schulz ME, Pearson PJ, Freed JK. Necessary role of acute ceramide formation in the human microvascular endothelium during health and disease.Circ Res. 2024; 134:81–96. doi: 10.1101/2023.06.02.543341CrossrefGoogle Scholar11. Sattler K, Graler M, Keul P, Weske S, Reimann CM, Jindrova H, Kleinbongard P, Sabbadini R, Brocker-Preuss M, Erbel R, et al. Defects of high-density lipoproteins in coronary artery disease caused by low sphingosine-1-phosphate content: correction by sphingosine-1-phosphate-loading.J Am Coll Cardiol. 2015; 66:1470–1485. doi: 10.1016/j.jacc.2015.07.057CrossrefMedlineGoogle Scholar12. Jozefczuk E, Guzik TJ, Siedlinski M. Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology.Pharmacol Res. 2020; 156:104793. doi: 10.1016/j.phrs.2020.104793CrossrefMedlineGoogle Scholar13. Drummond GR, Cai H, Davis ME, Ramasamy S, Harrison DG. Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide.Circ Res. 2000; 86:347–354. doi: 10.1161/01.res.86.3.347LinkGoogle Scholar14. Katunaric B, SenthilKumar G, Schulz ME, De Oliveira N, Freed JK. S1P (sphingosine-1-phosphate)-induced vasodilation in human resistance arterioles during health and disease.Hypertension. 2022; 79:2250–2261. doi: 10.1161/HYPERTENSIONAHA.122.19862LinkGoogle Scholar eLetters(0) eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate. Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page. Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesNecessary Role of Ceramides in the Human Microvascular Endothelium During Health and DiseaseGopika SenthilKumar, et al. Circulation Research. 2024;134:81-96 January 5, 2024Vol 134, Issue 1 Advertisement Article Information Metrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.123.323868PMID: 38175911 Originally publishedJanuary 4, 2024 KeywordsEditorialscoronary artery diseaseendotheliumhumansmicrovesselssphingolipidsPDF download Advertisement