病理生理学
缺血
医学
心脏病学
心肌缺血
内科学
作者
Panagiotis Theofilis,Alexios S Antonopoulos,Μarios Sagris,Aggelos Papanikolaou,Evangelos Oikonomou,Κonstantinos Tsioufis,Dimitris Tousoulis
出处
期刊:Biomedicines
[MDPI AG]
日期:2024-01-23
卷期号:12 (2): 259-259
标识
DOI:10.3390/biomedicines12020259
摘要
Silent myocardial ischemia (SMI), characterized by a lack of overt symptoms despite an inadequate blood supply to the myocardium, remains a challenging entity in cardiovascular medicine. The pathogenesis involves intricate interactions of vascular, neurohormonal, and metabolic factors, contributing to perfusion deficits without the characteristic chest pain. Understanding these mechanisms is pivotal for recognizing diverse clinical presentations and designing targeted interventions. Diagnostic strategies for SMI have evolved from traditional electrocardiography to advanced imaging modalities, including stress echocardiography, single-photon emission computed tomography (SPECT), positron emission tomography (PET), and cardiac magnetic resonance imaging (MRI). Treating SMI is a matter of ongoing debate, as the available evidence on the role of invasive versus medical management is controversial. This comprehensive review synthesizes current knowledge of silent myocardial ischemia, addressing its pathophysiology, diagnostic modalities, and therapeutic interventions.
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