化学
表位
连接器
免疫系统
抗原
蛋白质工程
计算生物学
抗体
免疫疗法
巨噬细胞
纳米技术
免疫识别
细胞生物学
酶
生物化学
免疫学
计算机科学
体外
生物
材料科学
操作系统
作者
Shuai Gong,Jingyi Qiu,S. Thayumanavan
摘要
Inspired by the immune system’s own strategy for macrophage activation, we describe here a simple self-assembly strategy for generating artificial immune complexes. The built-in recognition domains in the antibody, viz. the Fab and Fc domains, are judiciously leveraged for cargo conjugation to generate the nanoassembly and macrophage targeting, respectively. A responsive linker is engineered into the nanoassembly for releasing the protein cargo inside the macrophages, while ensuring stability during delivery. The design principles are simple and versatile to be applicable to a range of biologics, from small protein toxins to large enzymes, with high loading capacity. This self-assembly platform has the potential for delivering biologics to immune cells with implications in immunotherapy.
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