第1周
癌症研究
细胞周期
背景(考古学)
DNA损伤
细胞周期检查点
头颈部鳞状细胞癌
有丝分裂
生物
细胞
头颈部癌
癌症
DNA
细胞周期蛋白依赖激酶1
细胞生物学
遗传学
古生物学
作者
Shihan Khan,Paul Swiecicki,Deborah Doroshow
出处
期刊:The cancer journal
[Ovid Technologies (Wolters Kluwer)]
日期:2022-09-01
卷期号:28 (5): 381-386
标识
DOI:10.1097/ppo.0000000000000613
摘要
The WEE1 kinase family plays a crucial role in cell cycle regulation and DNA damage response pathways in malignant cells. Inhibition of WEE1 effectively overrides G2 cell cycle arrest and results in the accumulation of extensive DNA damage within dividing cells, potentiating mitotic catastrophe and cell death. As such, the development of WEE1 inhibitors as antineoplastic therapeutics has gained increasing interest in recent years. In particular, the role of WEE1 inhibitors for treatment of head and neck squamous cell carcinomas remains an area of active research with both preclinical and clinical studies investigating their use as both single-agent therapy and chemosensitizers when used in tandem with traditional chemotherapy, particularly in the context of TP53-mutant tumors. Here, we review the relevant available preclinical and clinical data on hand investigating the efficacy of WEE1 inhibitors for the treatment of head and neck cancers.
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