Design of prodrugs

CONTENTS: 1. Design of prodrugs: Bioreversible derivatives for various functional groups and chemical entities (by H. Bundgaard). 2. Design of prodrugs based on enzyme-substrate specificity (by P.K. Banerjee and G.L. Amidon) 3. Pharmacokinetic aspects of prodrug design and evaluation (by R.E. Notari). 4. Sustained drug action accomplished by the prodrug approach (by A.A. Sinkula). 5. Site-specific drug delivery via prodrugs (by V.J. Stella and K.J. Himmelstein). 6. Decreased toxicity and adverse reactions via prodrugs (by G. Jones) 7. Prodrugs for improved formulation properties (by B.D. Anderson) 8. Prodrugs and skin absorption (by J. Hadgraft). 9. Prodrugs in cancer chemotherapy (by T.A. Conners) 10. Albumin: A natural carrier for drug and enzyme therapy (by M. J. Poznansky and D. Bhardwaj) 11. Prodrugs versus soft drugs (by N. Bodor).