瘦素
糖蛋白130
细胞因子
小鼠苗条素受体
内科学
内分泌学
生物
神经肽Y受体
血管活性肠肽
受体
SOCS3
脂肪因子
神经肽
信号转导
细胞生物学
白细胞介素6
车站3
医学
肥胖
作者
Elizabeth A. Jones,Aviva J. Symes
出处
期刊:Neuroreport
[Ovid Technologies (Wolters Kluwer)]
日期:2000-12-01
卷期号:11 (18): 4049-4053
被引量:3
标识
DOI:10.1097/00001756-200012180-00029
摘要
Leptin was originally described as an adipocyte-derived cytokine that signals to the hypothalamus to regulate food intake and energy expenditure. Leptin signals through the Ob receptor, which is closely related to the gp130 cytokine receptor. Here we show that leptin can induce expression of the neuropeptide gene vasoactive intestinal peptide (VIP) through the VIP cytokine response element, the same element that mediates the response to the gp130 cytokines. Leptin acts synergistically with TGF-β to activate transcription through this element. Transcriptional responses to leptin are increased when transmitted through ObR mutated at Tyr986, the SHP-2 docking domain, yet this mutation does not alter the synergy between TGF-β and leptin. These data emphasize the functional similarity between leptin and the gp130 cytokines.
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