Microstructure stability in fully lamellar (FL) structure TiAl based intermatellics have been studied. The experiment results have shown that the smaller the lamellar spacing is, the more instable the lamellar structure is. The distinct lamellar spheroidization occurs at 1150°C holding for 24h. This phenomena may be caused by lamellar coarsening and decomposition. The linear residual β phase distributed in the Ti -47 A 1-2 Cr -2 Nb alloy may prevent lamellar spheroidization and improves the stability of lamellar structure significantly.