CD11c公司
生物
iC3b公司
CD18型
细胞粘附分子
整合素
细胞粘附
细胞生物学
免疫学
整合素αM
单核细胞
T细胞
补体系统
分子生物学
受体
细胞
流式细胞术
免疫系统
表型
生物化学
基因
作者
Chanchal Sadhu,Harold J. Ting,Brian P. Lipsky,Kelly Hensley,León F. Garcı́a-Martı́nez,Scott I. Simon,Donald E. Staunton
摘要
Abstract CD11c, a member of the leukointegrin family, is expressed prominently on tissue macrophages and dendritic cells and binds to complement fragment (iC3b), provisional matrix molecules (fibrinogen), and the Ig superfamily cell adhesion molecule, ICAM-1. CD11c has been proposed to function in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T cell proliferation by Langerhans cells. Using assays to quantify CD11c-mediated cell adhesion, we demonstrate that CD11c recognizes ICAM-2 and VCAM-1. The CD11c-binding site on VCAM-1 appears to be different from that used by the integrin α4. CD11c and α4β1 contributed to monocyte capture and transmigration on inflamed human aortic endothelial cells. We discovered that the anti-mouse CD11c mAb N418 blocks CD11c binding to iC3b, ICAM-1, and VCAM-1. Treatment of mice with N418 reduced SRBC-induced delayed-type hypersensitivity significantly. CD11c appeared to contribute predominantly to the sensitization phase and somewhat less to the response to SRBC challenge. This suggests a novel role for CD11c during leukocyte recruitment, antigen uptake, and the survival of APC.
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