牛磺去氧胆酸
甘胆酸
熊去氧胆酸
胆汁酸
内科学
溃疡性结肠炎
胆酸
胆酸
原发性硬化性胆管炎
炎症性肠病
牛磺胆酸
肝肠循环
医学
胆汁酸吸收不良
法尼甾体X受体
胃肠病学
肠道菌群
FGF19型
结肠炎
势垒函数
脱氧胆酸
肠粘膜
鹅去氧胆酸
失调
化学
疾病
生物化学
受体
内质网
未折叠蛋白反应
成纤维细胞生长因子
作者
Carsten Gnewuch,Gerhard Liebisch,Thomas Langmann,Benjamin Dieplinger,Thomas Mueller,Meinhard Haltmayer,Hans Dieplinger,Alexandra Zahn,Wolfgang Stremmel,Gerhard Rogler,Gerd Schmitz
摘要
To determine free and conjugated serum bile acid (BA) levels in inflammatory bowel disease (IBD) subgroups with defined clinical manifestations.Comprehensive serum BA profiling was performed in 358 IBD patients and 310 healthy controls by liquid chromatography coupled to electrospray ionization tandem mass spectrometry.Serum levels of hyodeoxycholic acid, the CYP3A4-mediated detoxification product of the secondary BA lithocholic acid (LCA), was increased significantly in Crohn's disease (CD) and ulcerative colitis (UC), while most other serum BA species were decreased significantly. Total BA, total BA conjugate, and total BA glycoconjugate levels were decreased only in CD, whereas total unconjugated BA levels were decreased only in UC. In UC patients with hepatobiliary manifestations, the conjugated primary BAs glycocholic acid, taurocholic acid, and glycochenodeoxycholic acid were as significantly increased as the secondary BAs LCA, ursodeoxycholic acid, and tauroursodeoxycholic acid compared to UC patients without hepatobiliary manifestations. Finally, we found that in ileocecal resected CD patients, the unconjugated primary BAs, cholic acid and chenodeoxycholic acid, were increased significantly compared to controls and patients without surgical interventions.Serum BA profiling in IBD patients that indicates impaired intestinal barrier function and increased detoxification is suitable for advanced diagnostic characterization and differentiation of IBD subgroups with defined clinical manifestations.
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