Stereoselective Synthesis of (−)‐Chloramphenicol, (+)‐Thiamphenicol and (+)‐Sphinganine via Chiral Tricyclic Iminolactone

Abstract The stereoselective syntheses of (−)‐chloramphenicol, (+)‐thiamphenicol and (+)‐sphinganine are described. The two continuous chiral centers within three target molecules were constructed through aldol reaction of chiral tricyclic iminolactone and aldehyde.