INTERLEUKIN-10 LEVELS IN SEMINAL PLASMA: IMPLICATIONS FOR CHRONIC PROSTATITIS-CHRONIC PELVIC PAIN SYNDROME

No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Feb 2002INTERLEUKIN-10 LEVELS IN SEMINAL PLASMA: IMPLICATIONS FOR CHRONIC PROSTATITIS-CHRONIC PELVIC PAIN SYNDROME LAURI J. MILLER, KATERI A. FISCHER, SANDRA J. GORALNICK, MARK LITT, JOSEPH A. BURLESON, PETER ALBERTSEN, and DONALD L. KREUTZER LAURI J. MILLERLAURI J. MILLER More articles by this author , KATERI A. FISCHERKATERI A. FISCHER More articles by this author , SANDRA J. GORALNICKSANDRA J. GORALNICK More articles by this author , MARK LITTMARK LITT More articles by this author , JOSEPH A. BURLESONJOSEPH A. BURLESON More articles by this author , PETER ALBERTSENPETER ALBERTSEN More articles by this author , and DONALD L. KREUTZERDONALD L. KREUTZER More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)69139-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Chronic prostatitis-chronic pelvic pain syndrome is a disease of unknown pathogenesis. We investigated whether the chronic inflammation and pain experienced by patients may be caused by an imbalance of proinflammatory versus anti-inflammatory cytokines within the prostate, namely interleukin (IL)-8, interferon-γ and IL-2 versus IL-10. We measured these inflammatory cytokines in seminal plasma as a reflection of the prostate environment. Materials and Methods: We measured levels of IL-8, interferon-γ, IL-2 and IL-10 in the seminal plasma of 31 patients with chronic prostatitis-chronic pelvic pain syndrome and 14 controls using enzyme-linked immunosorbent assay. Results were correlated with health related quality of life, as measured by the Multidimensional Pain Inventory, McGill pain questionnaire and International Prostate Symptom Score. Results: The cytokines analyzed were detectable in the seminal plasma of patients with chronic prostatitis-chronic pelvic pain syndrome and controls. Interferon-γ, IL-2 and IL-10 levels were statistically greater in patients. Furthermore, IL-10 levels correlated directly with measures of life interference (r = 0.52, p <0.01) and pain severity (r = 0.53, p <0 0.01), and inversely with spousal support (r = −0.39, p <0.04). Conclusions: Our study suggests that IL-10 may have a role in the pain symptoms experienced by patients with chronic prostatitis-chronic pelvic pain syndrome. References 1 : How common is prostatitis? A national survey of physician visits. J Urol1998; 159: 1224. Link, Google Scholar 2 Long-Range Plan Window in the 21st Century. National Kidney and Urologic Diseases Advisory Board. 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