渗透(战争)
球体
材料科学
纳米颗粒
纳米技术
纵横比(航空)
纳米尺度
纳米载体
纳米医学
药物输送
穿透深度
纳米棒
生物医学工程
复合材料
光学
化学
工程类
物理
医学
生物化学
体外
运筹学
作者
Rachit Agarwal,Patrick Jurney,Mansi Raythatha,Vedant Singh,Sameet Sreenivasan,Li Shi,Krishnendu Roy
标识
DOI:10.1002/adhm.201500441
摘要
Efficient penetration and uniform distribution of nanoparticles (NPs) inside solid tissues and tumors is paramount to their therapeutic and diagnostic success. While many studies have reported the effect of NP size and charge on intratissue distribution, role of shape, and aspect ratio on NP transport inside solid tissues remain unclear. Here experimental and theoretical studies are reported on how nanoscale geometry of Jet and Flash Imprint Lithography-fabricated, polyethylene-glycol-based anionic nanohydrogels affect their penetration and distribution inside 3D spheroids, a model representing the intervascular region of solid, tumor-like tissues. Unexpectedly, low aspect ratio cylindrical NPs (H/D ≈0.3; disk-like particles, 100 nm height, and 325 nm diameter) show maximal intratissue delivery (>50% increase in total cargo delivered) and more uniform penetration compared to nanorods or smaller NPs of the same shape. This is in contrast to spherical NPs where smaller NP size resulted in deeper, more uniform penetration. Our results provide fundamental new knowledge on NP transport inside solid tissues and further establish shape and aspect ratio as important design parameters in developing more efficient, better penetrating, nanocarriers for drug, or contrast-agent delivery.
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