沃尔巴克氏菌
班克罗夫提乌切列氏菌
淋巴丝虫病
马来丝虫
生物
卷盘尾丝虫
免疫学
盘尾丝虫病
疾病
丝虫病
发病机制
象皮病
蠕虫病
炎症
Loa Loa
蠕虫
医学
病理
细菌
遗传学
出处
期刊:Current Molecular Medicine
[Bentham Science]
日期:2002-05-01
卷期号:2 (3): 299-302
被引量:24
标识
DOI:10.2174/1566524024605662
摘要
Filariasis is a major public health problem throughout many regions of the tropics. The disease is caused by several species of filarial nematode including Wuchereria bancrofti and Brugia malayi, the agents of lymphatic filariasis, and Onchocerca volvulus, the cause of 'riverblindness'. Disease caused by these worms varies depending on the tissue location of the parasite, and is associated with episodes of acute and chronic inflammation. These pathologies, including elephantiasis and blindness, rank among the most disabling in the world. Studies aimed at characterizing the molecular nature of the inflammatory stimuli derived from filarial nematodes uncovered a long forgotten secret, their symbiont Wolbachia. LPS-like molecules from these intracellular bacteria are responsible for potent inflammatory responses from macrophages and in animal models of filarial disease. Wolbachia has also been associated with severe inflammatory reactions to filarial chemotherapy, being released into the blood following the death of the parasite. Recent studies in animal models even implicate Wolbachia in the onset of lymphodema and blindness. Taken together these studies suggest a major role for Wolbachia in the pathogenesis of filarial disease. It may be possible, through the use of antibiotic therapy, to clear worms of their bacteria, in the hope that this will prevent the onset and development of filarial pathology.
科研通智能强力驱动
Strongly Powered by AbleSci AI