Distribution and bioaccumulation of tetrabromobisphenol A in Carassius auratus tissues and its pathological effect

Distribution and bioaccumulation of TBBPA in different Carassius auratus tissues exposed to varied TBBPA concentrations were measured and analyzed.The corresponding pathological effects were also assessed.Results indicated that the concentrations of TBBPA increased firstly,then decreased in Carassius auratus liver and kidney at high as well as low dose group.Indicating that both the fish liver and kidney had a strong capacity of bioaccumulation.Nevertheless,the concentrations of TBBPA showed a similarity only at high dose in gill and muscle.The bioaccumulation capacity of the gill and muscle was comparatively lower.Pathological observations revealed that the pathological damage was time-dose-dependent in the liver,kidney and gill.Under the same TBBPA concentration,the gonad damage caused by TBBPA to the male was more serious than that to the female.