The effects of HSYA injection,aspirin and clopidogrel on platelet aggregation and ultrastructure in rabbits

Objective: To observe the effects of HSYA injection,aspirin and clopidogrel on platelet aggregation and ultrastructure in rabbits.Methods: In vivo experiments,when arachidonic acid(AA),adenosine diphosphate(ADP) and platelet activating factor(PAF) induced respectively,we observed the impacts of HSYA injection,aspirin and clopidogrel on platelet aggregation and ultrastructural changes of platelets.Results: HSYA injection inhibited AA and PAF-induced platelet aggregation.Scanning electron microscope showed: HSYA injection could reduce the number of aggregation type plateles which were induced by AA and PAF; and make fewer and shorter processes of dendritic platelets.Conclusion: HSYA injection can antagonism PAF-induced platelet aggregation and inhibit the activation of platelets.Thus for,there will be more choices for clinical using of anti-platelet aggregation drugs.