AIM To observe the influence of combining fentanyl, midazolam and propofol for induction and maintenance in intravenous anesthesia on physiological indices of surgical patients. METHODS 60 patients undergoing general anesthesia were induced with fentanyl, midazolam and propofol, then maintained by combining infusion of these drugs and by intermittent injection of vecuronium and fentanyl. ECG, BP, HR, SpO 2, and P ET CO 2 were monitored during the anesthesia . RESULTS The indices of hemodynamics were stable. Physiological responses were stable and no compliction was observed. CONCLUSION The total intravenous anesthesia fits the need of all kinds of surgeries.