Identification of the Retinoic Acid-Inducible Gprc5a As a New Lung Tumor Suppressor Gene

BackgroundLung cancers develop via multiple genetic and epigenetic changes, including inactivation of tumor suppressor genes. We previously cloned human G protein–coupled receptor family C type 5A (GPRC5A), whose expression is suppressed in some human lung carcinoma cells, and its mouse homolog Gprc5a.