A gas-liquid biphasic nanocleaner for breaking the self-amplified vicious cycle of barrier disruption-inflammation in inflammatory bowel disease

, GLBN effectively suppresses inflammation and promotes macrophage repolarization from the M1 toward the M2 phenotype. Moreover, density function Sal theory (DFT) calculations attribute the biphasic scavenging capabilities to heterogeneous facets and metal-sulfur bonding. Consequently, highly efficient therapy of IBD is achieved in a mouse model. Our study marks a critical breakthrough in the therapeutic application of biphasic scavenging nanozymes for inflammatory diseases triggered by multiphase pathogenic factors.