Armillariella tabescens polysaccharides alleviate ER stress in 5-FU-induced intestinal epithelial injury and mucositis via ARRB1 modulation

This study provides new insights into the therapeutic potential of ATPS in alleviating 5-FU-induced intestinal mucositis by modulating ARRB1 and suppressing ERS. The protective effects of ATPS were validated in both IEC-6 cells and a murine model, demonstrating its ability to enhance intestinal barrier integrity, inhibit apoptosis, and reduce inflammation. These findings suggest that ARRB1-mediated ERS suppression is a critical mechanism underlying ATPS-induced intestinal protection, presenting a novel strategy for mitigating chemotherapy-induced gastrointestinal toxicity.