贝克曼重排
化学
亲核细胞
立体专一性
溴化物
碎片(计算)
双环分子
组合化学
有机化学
立体化学
催化作用
计算机科学
操作系统
作者
Dhiman Saha,Zachary Protich,Jimmy Wu
标识
DOI:10.1021/acs.orglett.3c03434
摘要
The Beckmann elimination and nucleophile-intercepted Beckmann fragmentation (NuBFr) of oximes starting from regioisomeric indolinyl bicyclic ketones lead to products that are subjected to further synthetic manipulations and ultimately result in the stereospecific formation of densely functionalized hexahydrocarbazoles. The Pd-catalyzed Suzuki-Miyaura cross-coupling reaction of a key alkenyl bromide intermediate with various boronic acids gives arylated products.
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