肾脏疾病
荧光
纳米材料
医学
纳米技术
材料科学
内科学
物理
光学
作者
Padmanabh P. Bhatt,Deepak Kukkar,Ki‐Hyun Kim
标识
DOI:10.1016/j.trac.2024.117572
摘要
The preliminary identification of chronic kidney disease (CKD) is crucial because of its high-risk factors for complications. Currently, diverse forms of chronic kidney disease biomarkers (CKDBs) (e.g., serum creatinine [CR], kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, and cystatin C) are available for the medical assessment of kidney diseases. The fluorescent (FL) nanomaterials (NMs) possess numerous unparallel attributes such as high sensitivity, accuracy, scalability, and facile recognition of target CKDBs. A combination of FL NMs with the aforementioned CKDBs can greatly enhance their sensing potential in various respects. This review delineates recent developments in FL NMs-based sensors for CKDBs along with their performance evaluation based on the fundamental validation metrics (e.g., limit of detection, linear dynamic range, Stern-Volmer quenching coefficient, and figure of merit tools). Future challenges in FL NMs for sensing CKDBs such as point-of-care detection have also been presented.
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