Nucleophilic Carbenes Derived from Dichloromethane

Abstract Nickel PyBox catalysts promote nucleophilic cyclopropanation reactions using CH 2 Cl 2 as a methylene source and Mn as a stoichiometric reductant. The substrate scope includes a broad range of alkenes bearing electron‐withdrawing substituents, including esters, amides, ketones, nitriles, sulfones, phosphonate esters, trifluoromethyl groups, and electron‐deficient arenes. Enantioselective cyclopropanations of α,β‐unsaturated esters have been developed using chiral PyBox ligands. Mechanistic studies suggest the intermediacy of a (PyBox)Ni=CH 2 species, which adds to the alkene by a stepwise [2+2]‐cycloaddition/C−C reductive elimination mechanism. DFT models provide a rationale for the nucleophilic character of the nickel carbene and the sense of enantioinduction.