医学
工作组
特应性皮炎
皮密莫司
药方
梅德林
重症监护医学
皮肤病科
循证实践
多学科方法
钙调神经磷酸酶
替代医学
药理学
外科
病理
移植
社会学
法学
计算机科学
社会科学
计算机网络
政治学
作者
Robert Sidbury,Ali Alikhan,Lionel Bercovitch,David Cohen,Jennifer M. Darr,Aaron M. Drucker,Lawrence F. Eichenfield,Lindsy Frazer-Green,Amy S. Paller,Kathryn Schwarzenberger,Jonathan I. Silverberg,Anne Marie Singh,Peggy Wu,Dawn M. Davis
标识
DOI:10.1016/j.jaad.2022.12.029
摘要
Background
New evidence has emerged since the 2014 guidelines that further informs the management of atopic dermatitis (AD) with topical therapies. These guidelines update the 2014 recommendations for management of AD with topical therapies. Objective
To provide evidence-based recommendations related to management of AD in adults using topical treatments. Methods
A multidisciplinary workgroup conducted a systematic review and applied the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) approach for assessing the certainty of evidence and formulating and grading recommendations. Results
The workgroup developed 12 recommendations on the management of AD in adults with topical therapies, including nonprescription agents and prescription topical corticosteroids (TCS), calcineurin inhibitors (TCIs), Janus kinase (JAK) inhibitors, phosphodiesterase-4 inhibitors (PDE-4), antimicrobials, and antihistamines. Limitations
The pragmatic decision to limit the literature review to English-language randomized trials may have excluded data published in other languages and relevant long-term follow-up data. Conclusions
Strong recommendations are made for the use of moisturizers, TCIs, TCS, and topical PDE-4 and JAK inhibitors. Conditional recommendations are made for the use of bathing and wet wrap therapy and against the use of topical antimicrobials, antiseptics, and antihistamines.
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