纤维细胞
医学
川地34
Graves眼病
骨髓
疾病
发病机制
病理
轨道(动力学)
癌症研究
干细胞
生物
细胞生物学
格雷夫斯病
航空航天工程
工程类
作者
Erin S. Proctor,Terry J. Smith
出处
期刊:Current Opinion in Endocrinology, Diabetes and Obesity
[Ovid Technologies (Wolters Kluwer)]
日期:2022-08-11
卷期号:29 (5): 441-448
被引量:1
标识
DOI:10.1097/med.0000000000000765
摘要
Purpose of review We attempt to provide an historical perspective on progress made in understanding the pathogenesis of thyroid-associated ophthalmopathy (TAO), focusing on the roles of orbital fibroblasts (OF) in the diseased orbit (termed GD-OF) and how these cells differ from those residing in the healthy orbit. GD-OF comprise both residential OF and those apparently derived from CD34 + fibrocytes. Recent findings CD34 + fibrocytes of the monocyte lineage putatively traffic to the TAO orbit from bone marrow. We believe that these fibroblastic cell populations dictate the activity and severity of TAO. Their impact on disease may be moderated by Slit2, a neuron axon guidance repellent synthesized by and released from residential CD34 - OF. Approximately 50% of patients with GD develop clinically meaningful TAO. Relatively few require systemic medical and surgical therapies, while milder disease can be managed with conservative, local care. Determining the intrinsic properties of GD-OF and their expression of Slit2 may explain why some patients with GD develop severe, vision-threatening TAO while others virtually escape any of its manifestations. Such insights should allow for improved and better-tolerated therapies. Summary Identifying unique characteristics of fibrocytes and GD-OF subsets reveals their apparent roles in tissue activation, inflammation, and remodeling associated with TAO. Better understanding of these cells, their origins, behavior, and factors modulating their activities remains necessary for the development of more targeted, effective, and safe treatments.
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